1. Presented by Edward McCarthy, M.D. and prepared by Jeffrey Seibel, M.D. Ph.D.

A 60 year-old man had pain in his knee for two years. Radiographs demonstrated a large lytic lesion in the proximal tibia involving the epiphysis and the metaphysis. There was also joint space narrowing with bony sclerosis and osteophyte formation typical of osteoarthritis.

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